TUMUL SRIVASTAVA, Ph.D.

C-301 Kanakiya Samarpan, Email: 
Western Express Highway, Mobile: +919029067349
Near Thakur Complex, Borivali East,
Mumbai, India, 400066

PROFILE

 * Ph.D. in Organic chemistry with expertise in synthesis of peptides and
heterocyclic molecules.
 * 14 publications in peer reviewed journals.
 * 10 years of experience in peptide and organic synthesis.
 * Trustworthy, meticulous, hard working and dynamic.
 * Excellent communication skills.
 * Leadership skills-supervisory experience with post-doctoral fellows and
Student interns.

WORK EXPERIENCE

Research Fellow
July 2006-April 2010
City of Hope National Medical Centre and Beckman Research Institute, Duarte, CA,
USA

Research Associate II
May 2005-July 2006
City of Hope National Medical Centre and Beckman Research Institute, Duarte, CA,
USA

Senior Research Fellow
May 2003-March 2005
Central Drug Research Institute, Lucknow, India

Research Fellow
March 2000- April 2003
Central Drug Research Institute, Lucknow, India

PROFESSIONAL SKILLS

 * Expertise in peptide synthesis by solution and solid phase.
 * Expertise in synthesis of small hetrocyclic molecules by solution and solid
phase.
 * Expertise in synthesis of Microspheres.
 * Experience of Oligonucleotide synthesis.
 * Expertise with operational analytical techniques such as HPLC, UV
spectrophotometer and Polarimeter.
 * Technical and operational proficiency with specific spectroscopic technique
such as MALDI Mass Spectrophotometer.
 * Proficient in purification of peptides by preparative HPLC.
 * Knowledge of spectroscopic techiques such as IR and NMR.
 * Proficiency in general application softwares and chemistry application
softwares and database.

INSTRUMENTS ADEPT WITH

Peptide synthesizer, Maldi Mass Spectrophotometer, Gene Assembler, Analytical
and Preparative HPLC, Polarimeter, UV-Visible Spectrophotometer.

EDUCATION

Ph.D.
2005

Organic Chemistry
Central Drug Research Institute, Lucknow, India. Degree provided by Dr. R. M. L.
Awadh University, Faizabad, India (2006).

M.Sc.
1998
1st Division
Organic Chemistry
Lucknow University, Lucknow, India

B.Sc.
1996
1st Division
Physics & Chemistry
Lucknow University, Lucknow, India

AWARDS AND HONORS

 * Senior Research Fellowship, Council of Scientific and Industrial Research,
Govt of India (2003-2005).
 * Research Fellowship, Central Drug Research Institute, Govt of India (2000-
2003).
 * GATE (Graduate Aptitude Test in Engineering) in 1999.
 * Bronze medal in BSc.
 * Gold medal (Chemistry) in BSc.

RESEARCH EXPERIENCE

May 2005 - April 2010; City of Hope National Medical Centre and Beckman Research
Institute, Duarte, CA, USA.

 * Synthesized and characterized IE2, UL28, US3, US32 and UL99 peptide libraries
to find an affective CMV vaccine.
 * Synthesized and characterized p53, MITF, BCL-XL, Wilms Tumor, Survivin,
Neutrophil Elastase and PR3 peptide libraries in the search of a better cancer
vaccine.
 * Synthesized fusion peptides with PADRE peptide and/or Tetanus toxin for
evaluating immunogenicity of the epitope in a mouse model.
 * Microsphere preparation of fusion peptides for the better drug delivery of
the same in mouse.

Mar 2000 - April 2005; Central drug Research Institute, Lucknow, India.

 * Synthesis and characterization of various thiazolidine 4-carboxylic acid
derivatives as antifungal agents.
 * Synthesis and characterization of a number of 4-Thiazolidinones as antifungal
and antituberculosis agent.
 * Developed a new time efficient methodolgy to synthesize 4-thiazolidinone.

PUBLICATIONS

1. Heterologous prime/boost immunization with p53-based vaccines combined with
toll-like receptors stimulation enhances tumor regression.
J. Immunother., 2010, 33(6) : 609-617. H. Ishizaki, G-Y Song, Tumul Srivastava,
K. D. Carroll, V. Shahabi, E. R. manuel, D. J. Diamond and J Ellenhorn.

2. CD154 expression is associated with neutralizing antibody titer levels
post-Influenza vaccination in stem cell transplant patients and healthy adults..
Biol. Blood Marrow Transplant., 2010, Accepted. A. Seidel, D. Smith, E. Yung, L.
Aquino, Tumul Srivastava, V. Pullarkat, R. Spielberger, S. J. Forman and D. J.
Diamond.

3. Modified H5 promoter improves stability of insert genes while maintaining
immunogenicity during extended passage of genetically engineered MVA vaccines.
Vaccine, 2010, 28(6) : 1547-1557. Z. Wang, J. Martinez, W. Zhou, C. La Rosa,
Tumul Srivastava, A. Dasgupta, R. Rawal, Z. Li, W. J. Britt, D. J. Diamond.

4. Mamu-A01/K(b) transgenic and MHC Class I knockout mice as a tool for HIV
vaccine development.
Virology, 2009, 387(1): 16-28. L. Jinliang; Tumul Srivastava, R. Rawal, E.
Manuel, D. Isbell, W. Tsark, C. La Rosa, Z. Wang, , P. A Barry, K. D Hagen, J.
Longmate, D. J Diamond.

5. A novel approach to evaluate the immunogenicity of viral antigens of clinical
importance in HLA transgenic murine models.
Immunology letters, 2008, 120: 108-116. A. Krishnan, Z. Wang, Tumul Srivastava,
R. Rawal, P. Manchanda, D. J. Diamond, C. La Rosa.

6. A fusion protein of HCMV IE1 exon4 and IE2 exon5 stimulates potent cellular
immunity in an MVA vaccine vector.
Virology, 008, 377: 379-390. Z. Wang, W. Zhou, Tumul Srivastava, C. La Rosa, A.
Mandarino, S. J. Forman, J. A. Zaia, W. J. Britt, D. J. Diamond.

7. Functional characterization of BK virus-specific cytotoxic CD4 T-cells in
seropositive healthy adults.
Viral Immunology, 2007, 20(3): 379-388. W Zhou, M Sharma, J Martinez, Tumul
Srivastava, D. J Diamond, WA Knowles, S. F Lacey.

8. An MVA vaccine overcomes tolerance to human p53 in mouse and man.
Cancer Immunology & Immunotherapy, 2007, 56: 1193-1205. G-Y Song, G Gibson, W.
Haq, ECC Huang, Tumul Srivastava, M Hollstein, P Daftarian, Z Wang, D. J.
Diamond, and J Ellenhorn.

9. Cross-reactive CTL recognize two HLA-A*02-restricted epitopes within the BK
virus and JC virus VP1 polypeptides are frequent in immunocompetent individuals.
Virology, 2006, 350: 128-136. M. C. Sharma, W. Zhou, J. Martinez, L. Krymskaya,
Tumul Srivastava, W. Haq, D. J. Diamond and S. F. Lacey.

10. Synthesis and biological evaluation of 4-thiazolidinone derivatives as
potential antimycobacterial agents.
Arkivoc, 2005, (ii): 120-130. Tumul Srivastava, A. K. Gaikwad, W. Haq, S. Sinha
and S. B. Katti.

11. An expeditious synthesis of thiazolidinones and metathiazanones.
J. Chem. Research(S), 2004, 2004(5): 368-369. R. K. Rawal, Tumul Srivastava, W.
Haq and S. B. Katti.

12. A facile and simple method for the reduction of N-protected amino acids and
peptides to the corresponding amino alcohols.
J. Chem. Research(S), 2003, 2003(8): 516-517. Tumul Srivastava, T. K.
Srivastava, W. Haq and S. B. Katti.

13. Crystal structure of 2-(4-Chlorophenyl)-3-cyclohexylthiazolidin-4-one.
Acta crystallographica, 2003, E59(8): o1239-o1240. A. Sharon, Tumul Srivastava,
S. B. Katti and P. R. Maulik.

14. Carbodiimide mediated synthesis of 4-thiazolidinone by one pot three
component condensation. Tetrahedron, 2002, 58(38): 7619-7624. Tumul Srivastava,
W. Haq and S. B. Katti.